Oxidative stress regulates autophagy in cultured muscle cells of patients with chronic obstructive pulmonary disease

The proteolytic autophagy pathway is enhanced in the lower limb muscles of patients with chronic obstructive pulmonary disease (COPD). Reactive oxygen species (ROS) have been shown to regulate autophagy in the skeletal muscles, but the role of oxidative stress in the muscle autophagy of patients wit...

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Bibliographic Details
Published in:Journal of cellular physiology 2018-12, Vol.233 (12), p.9629-9639
Main Authors: Gouzi, Fares, Blaquière, Marine, Catteau, Matthias, Bughin, François, Maury, Jonathan, Passerieux, Emilie, Ayoub, Bronia, Mercier, Jacques, Hayot, Maurice, Pomiès, Pascal
Format: Article
Language:English
Subjects:
Antioxidants
Ascorbic acid
Atrophy
Autophagy
BNIP3 protein
Carbonyls
Chronic obstructive pulmonary disease
chronic obstructive pulmonary disease (COPD)
Gene expression
Life Sciences
Lung diseases
mRNA
Muscles
Myoblasts
Myotubes
Obstructive lung disease
Oxidative stress
Patients
Phagocytosis
Proteins
Proteolysis
Quadriceps muscle
Reactive oxygen species
satellite cells
Skeletal muscle
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Summary:The proteolytic autophagy pathway is enhanced in the lower limb muscles of patients with chronic obstructive pulmonary disease (COPD). Reactive oxygen species (ROS) have been shown to regulate autophagy in the skeletal muscles, but the role of oxidative stress in the muscle autophagy of patients with COPD is unknown. We used cultured myoblasts and myotubes from the quadriceps of eight healthy subjects and twelve patients with COPD (FEV1% predicted: 102.0% and 32.0%, respectively; p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26868