Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans

Abstract We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies...

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Bibliographic Details
Published in:Canadian journal of diabetes 2016-10, Vol.40 (5), p.462-465
Main Authors: Liminet, Christelle, MD, Vouillarmet, Julien, MD, Chikh, Karim, MD, Disse, Emmanuel, MD, PhD
Format: Article
Language:English
Subjects:
Aged, 80 and over
auto-anticorps
auto-immunité
autoantibodies
Autoantigens - metabolism
Autoimmunity
Blood Glucose
Diabetes Mellitus - immunology
Diabetes Mellitus - metabolism
Endocrinology & Metabolism
Humans
insulin
Insulin Resistance - immunology
insuline
insulinorésistance grave
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Life Sciences
Male
Other
severe insulin resistance
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Summary:Abstract We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic possibilities.
ISSN:1499-2671
2352-3840
DOI:10.1016/j.jcjd.2016.02.007