Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological process...

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Bibliographic Details
Published in:Sports medicine (Auckland) 2016-05, Vol.46 (5), p.629-639
Main Authors: Chirico, Erica N., Faës, Camille, Connes, Philippe, Canet-Soulas, Emmanuelle, Martin, Cyril, Pialoux, Vincent
Format: Article
Language:English
Subjects:
Anemia, Sickle Cell - metabolism
Animals
Antioxidants
Bioavailability
Blood
Disease Models, Animal
Enzymes
Exercise
Exercise - physiology
Fitness training programs
Funding
Heme - metabolism
Hemoglobin, Sickle - metabolism
Hemolysis
Humans
Hydrogen peroxide
Hypoxia - metabolism
Iron - blood
Life Sciences
Lipid peroxidation
Lipids
Medicine
Medicine & Public Health
Mice
NADPH Oxidases - metabolism
Nitric Oxide - metabolism
Oxidation
Oxidative stress
Oxidative Stress - physiology
Physical fitness
Plasma
Reperfusion Injury - metabolism
Review Article
Rodents
Sickle cell disease
Sickle Cell Trait - metabolism
Sports Medicine
Studies
Vitamin E
Xanthine Oxidase - metabolism
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Description
Summary:Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological processes associated with this disease (ischaemic and hypoxic injuries, hemolysis and inflammation) has been shown to contribute to its pathophysiology. It is widely known that chronic exercise reduces oxidative stress in healthy people, mainly via improvement of antioxidant enzyme efficiency. In addition, recent studies in other diseases, as well as in sickle cell trait carriers and in a mouse model of sickle cell disease, have shown that regular physical activity could decrease oxidative stress. The purpose of this review is to summarize the role of oxidative stress in sickle cell disease and the effects of acute and chronic exercise on the pro-oxidant/antioxidant balance in sickle cell trait and sickle cell disease.
ISSN:0112-1642
1179-2035
DOI:10.1007/s40279-015-0447-z