Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats

• Published in: Environmental science and pollution research international 2018-09, Vol.25 (27), p.27463-27470
• Main Authors: Abdel-Daim, Mohamed M., Abushouk, Abdelrahman Ibrahim, Alkhalf, Maha I., Toraih, Eman A., Fawzy, Manal S., Ijaz, Hira, Aleya, Lotfi, Bungau, Simona G.
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase; Acetylcholinesterase - blood; Algae; Alkaline phosphatase; Animals; Antioxidants; Aquatic microorganisms; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Biochemical analysis; Biochemistry; Brain; Brain injury; Catalase; Catalase - metabolism; Colorimetry; Creatine; Creatine kinase; Creatinine; Diazinon; Diazinon - toxicity; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Environmental Sciences; Erythrocytes; Erythrocytes - drug effects; Fungicides; Glutathione peroxidase; Glutathione Peroxidase - metabolism; Heart; Heart - drug effects; Heavy metals; Hematocrit; Hematologic Tests; Hemoglobin; Inflammation; Injuries; Insecticides; Insecticides - toxicity; Kidney - drug effects; Kidney - metabolism; Kidneys; Kinases; Leukocytes; Lipid peroxidation; Liver; Liver - drug effects; Liver - metabolism; Male; Malondialdehyde - metabolism; Markers; Microalgae; Muscles; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Peroxidation; Pesticide toxicity; Pesticides; Pharmacology; Platelets; Rats, Wistar; Research Article; Spectrophotometry; Spirulina; Spirulina platensis; Subacute toxicity; Superoxide dismutase; Superoxide Dismutase - metabolism; Toxicity; Urea; Uric acid; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-018-2761-0

Spirulina platensis (SP) is a traditionally used microalga for a wide range of pharmacological activities, including amelioration of heavy metals and pesticides toxicity. This study evaluated the antioxidant and organoprotective effects of SP against diazinon (DZN)-induced subacute toxicity on the blood, heart, liver, and kidneys of male Wistar albino rats. Diazinon (20 mg/kg, subcutaneous) was administered to animals either alone or along with an oral pure SP powder at doses of 500 and 1000 mg/kg. Alterations in hematological and serum biochemical parameters, as well as oxidative stress markers in the hepatic, renal, and cardiac tissues were evaluated, using colorimetric spectrophotometric techniques. The obtained results revealed that in comparison to the control group, DZN-treated rats exhibited significantly lower ( p