Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation

We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. We then tested the potency of such dietary intervention in the prevention of insulin resistance in C57BL/6 male mouse fed a high-fat diet (HFD). In addition, s...

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Bibliographic Details
Published in:British journal of nutrition 2015-06, Vol.113 (12), p.1862-1875
Main Authors: Croze, Marine L., Géloën, Alain, Soulage, Christophe O.
Format: Article
Language:English
Subjects:
Accretion
Adipokines - blood
Adipose tissue
Adipose Tissue, White - enzymology
Adipose Tissue, White - metabolism
Animals
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Diet
Diet, High-Fat
Dietary Supplements
Fatty Acid Synthases - metabolism
Hyperglycemia - metabolism
Inositol - administration & dosage
Inositol - analysis
Inositol - deficiency
Inositol - metabolism
Inositol - urine
Insulin Resistance
Kidney - chemistry
Kidneys
Life Sciences
Lipid Metabolism - drug effects
Liver - chemistry
Male
Metabolism
Metabolism and Metabolic Studies
Mice
Mice, Inbred C57BL
Muscles
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - prevention & control
Prevention
Rodents
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Summary:We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. We then tested the potency of such dietary intervention in the prevention of insulin resistance in C57BL/6 male mouse fed a high-fat diet (HFD). In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. We then investigated the presence of such anomalies (i.e. inosituria and an inositol intra-tissue depletion) in this diet-induced obesity (DIO) mouse model, as well as the potential benefit of a MI supplementation for inositol intra-tissue deficiency correction. HFD (60 % energy from fat) feeding was associated with inosituria and inositol intra-tissue depletion in the liver and kidneys. MI supplementation (0·58 mg/g per d) restored inositol pools in kidneys (partially) and liver (fully). HFD feeding for 4 months induced ectopic lipid redistribution to liver and muscles, fasting hyperglycaemia and hyperinsulinaemia, insulin resistance and obesity that were not prevented by MI supplementation, despite a significant improvement in insulin sensitivity parameter K insulin tolerance test and a reduction in white adipose tissue (WAT) mass ( − 17 %, P
ISSN:0007-1145
1475-2662
DOI:10.1017/S000711451500121X