Do we need congenital adrenal hyperplasia screening for premature infants?

Congenital adrenal hyperplasia neonatal screening has been introduced in France since 1995. A recent survey has questioned its relevance in premature infants because of a high number of false positives and a low positive predictive value of 17-hydroxyprogesterone dosage. A workgroup at the French sc...

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Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2014-02, Vol.21 (2), p.233-236
Main Authors: Huet, F, Godefroy, A, Cheillan, D, Somma, C, Roussey, M
Format: Article
Language:fre
Subjects:
17-alpha-Hydroxyprogesterone - blood
Adrenal Hyperplasia, Congenital - diagnosis
Adrenal Hyperplasia, Congenital - epidemiology
Cross-Sectional Studies
France
Gestational Age
Humans
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - epidemiology
Life Sciences
Neonatal Screening
Pilot Projects
Predictive Value of Tests
Unnecessary Procedures
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Summary:Congenital adrenal hyperplasia neonatal screening has been introduced in France since 1995. A recent survey has questioned its relevance in premature infants because of a high number of false positives and a low positive predictive value of 17-hydroxyprogesterone dosage. A workgroup at the French screening association (Association française de dépistage et de prévention des handicaps de l'enfant) collected all the epidemiological, clinical and biological data of premature children presenting with adrenal hyperplasia from the national cohort. Their results were compared with those of healthy premature children. All the data showed that the screening in children born before 32 weeks of gestational age is irrelevant, but that it is efficient after this term. A pilot study has been implemented in population to evaluate the opportunity to discontinue this screening in extreme preterm neonates.
ISSN:0929-693X
1769-664X
DOI:10.1016/j.arcped.2013.11.002