New transcriptomic tools to understand testis development and functions

The testis plays a central role in the male reproductive system - secreting several hormones including male steroids and producing male gametes. A complex and coordinated molecular program is required for the proper differentiation of testicular cell types and maintenance of their functions in adult...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular endocrinology 2018-06, Vol.468, p.47-59
Main Authors: Lecluze, Estelle, Jégou, Bernard, Rolland, Antoine D., Chalmel, Frédéric
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Development
Development Biology
Endocrinology and metabolism
Gametogenesis
Genomics
Germ cells
Human health and pathology
Life Sciences
RNA-sequencing
Spermatogenesis
Testis
Transcriptomics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The testis plays a central role in the male reproductive system - secreting several hormones including male steroids and producing male gametes. A complex and coordinated molecular program is required for the proper differentiation of testicular cell types and maintenance of their functions in adulthood. The testicular transcriptome displays the highest levels of complexity and specificity across all tissues in a wide range of species. Many studies have used high-throughput sequencing technologies to define the molecular dynamics and regulatory networks in the testis as well as to identify novel genes or gene isoforms expressed in this organ. This review intends to highlight the complementarity of these transcriptomic studies and to show how the use of different sequencing protocols contribute to improve our global understanding of testicular biology. •RNA-sequencing technologies.•Testis development and functions.•Transcriptome of testicular cells.
ISSN:0303-7207
1872-8057
0303-7207
DOI:10.1016/j.mce.2018.02.019