In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI

Purpose The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency o...

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Published in:Molecular imaging and biology 2019-04, Vol.21 (2), p.269-278
Main Authors: Thébault, Caroline J., Ramniceanu, Grégory, Michel, Aude, Beauvineau, Claire, Girard, Christian, Seguin, Johanne, Mignet, Nathalie, Ménager, Christine, Doan, Bich-Thuy
Format: Article
Language:English
Subjects:
Accumulation
Animals
Biochemistry, Molecular Biology
Cancer
Cell Line, Tumor
Cell Survival
Colon
Colonic Neoplasms - diagnostic imaging
Colorectal cancer
Contrast agents
Drug delivery
Drug delivery systems
Efficiency
Evaluation
Female
Image contrast
Imaging
Iron
Life Sciences
Liposomes
Liver - metabolism
Magnetic permeability
Magnetic Resonance Imaging
Magnetics
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - ultrastructure
Medical imaging
Medical innovations
Medicine
Medicine & Public Health
Mice
Mice, Inbred BALB C
NIH 3T3 Cells
NMR
Nuclear magnetic resonance
Quantitative analysis
Radiology
Research Article
Tumors
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container_title Molecular imaging and biology
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creator Thébault, Caroline J.
Ramniceanu, Grégory
Michel, Aude
Beauvineau, Claire
Girard, Christian
Seguin, Johanne
Mignet, Nathalie
Ménager, Christine
Doan, Bich-Thuy
description Purpose The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI). Procedures Dynamic susceptibility contrast MRI was applied to assess the bloodstream circulation time. A novel semi-quantitative method called % I 0.25 , based on the intensity distribution in T 2 * -weighted MRI images was developed to compare the accumulation of T 2 contrast agent in tumors with or without MT. To evaluate the efficiency of magnetic targeting, the percentage of pixels under the intensity value I 0.25 ( I 0.25  = 0.25( I max  −  I min )) was calculated on the intensity distribution histogram. Results This innovative method of processing MRI images showed the MT efficiency by a % I 0.25 that was significantly higher in tumors using MT compared to passive accumulation, from 15.3 to 28.6 %. This methodology was validated by ex vivo methods with an iron concentration that is 3-fold higher in tumors using MT. Conclusions We have developed a method that allows a semi-quantitative evaluation of targeting efficiency in tumors, which could be applied to different T 2 contrast agents.
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The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI). Procedures Dynamic susceptibility contrast MRI was applied to assess the bloodstream circulation time. A novel semi-quantitative method called % I 0.25 , based on the intensity distribution in T 2 * -weighted MRI images was developed to compare the accumulation of T 2 contrast agent in tumors with or without MT. To evaluate the efficiency of magnetic targeting, the percentage of pixels under the intensity value I 0.25 ( I 0.25  = 0.25( I max  −  I min )) was calculated on the intensity distribution histogram. Results This innovative method of processing MRI images showed the MT efficiency by a % I 0.25 that was significantly higher in tumors using MT compared to passive accumulation, from 15.3 to 28.6 %. This methodology was validated by ex vivo methods with an iron concentration that is 3-fold higher in tumors using MT. Conclusions We have developed a method that allows a semi-quantitative evaluation of targeting efficiency in tumors, which could be applied to different T 2 contrast agents.</description><identifier>ISSN: 1536-1632</identifier><identifier>EISSN: 1860-2002</identifier><identifier>DOI: 10.1007/s11307-018-1238-3</identifier><identifier>PMID: 29942990</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Accumulation ; Animals ; Biochemistry, Molecular Biology ; Cancer ; Cell Line, Tumor ; Cell Survival ; Colon ; Colonic Neoplasms - diagnostic imaging ; Colorectal cancer ; Contrast agents ; Drug delivery ; Drug delivery systems ; Efficiency ; Evaluation ; Female ; Image contrast ; Imaging ; Iron ; Life Sciences ; Liposomes ; Liver - metabolism ; Magnetic permeability ; Magnetic Resonance Imaging ; Magnetics ; Magnetite Nanoparticles - chemistry ; Magnetite Nanoparticles - ultrastructure ; Medical imaging ; Medical innovations ; Medicine ; Medicine &amp; Public Health ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; NMR ; Nuclear magnetic resonance ; Quantitative analysis ; Radiology ; Research Article ; Tumors</subject><ispartof>Molecular imaging and biology, 2019-04, Vol.21 (2), p.269-278</ispartof><rights>World Molecular Imaging Society 2018</rights><rights>Molecular Imaging and Biology is a copyright of Springer, (2018). All Rights Reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-cb3822631cdc3376c0235e7f678479686e25be595c52c101063167f4ac49c2883</citedby><cites>FETCH-LOGICAL-c449t-cb3822631cdc3376c0235e7f678479686e25be595c52c101063167f4ac49c2883</cites><orcidid>0000-0001-5689-7046 ; 0000-0002-3323-2997 ; 0000-0002-4080-3508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29942990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-01873316$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Thébault, Caroline J.</creatorcontrib><creatorcontrib>Ramniceanu, Grégory</creatorcontrib><creatorcontrib>Michel, Aude</creatorcontrib><creatorcontrib>Beauvineau, Claire</creatorcontrib><creatorcontrib>Girard, Christian</creatorcontrib><creatorcontrib>Seguin, Johanne</creatorcontrib><creatorcontrib>Mignet, Nathalie</creatorcontrib><creatorcontrib>Ménager, Christine</creatorcontrib><creatorcontrib>Doan, Bich-Thuy</creatorcontrib><title>In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI</title><title>Molecular imaging and biology</title><addtitle>Mol Imaging Biol</addtitle><addtitle>Mol Imaging Biol</addtitle><description>Purpose The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI). Procedures Dynamic susceptibility contrast MRI was applied to assess the bloodstream circulation time. A novel semi-quantitative method called % I 0.25 , based on the intensity distribution in T 2 * -weighted MRI images was developed to compare the accumulation of T 2 contrast agent in tumors with or without MT. To evaluate the efficiency of magnetic targeting, the percentage of pixels under the intensity value I 0.25 ( I 0.25  = 0.25( I max  −  I min )) was calculated on the intensity distribution histogram. Results This innovative method of processing MRI images showed the MT efficiency by a % I 0.25 that was significantly higher in tumors using MT compared to passive accumulation, from 15.3 to 28.6 %. This methodology was validated by ex vivo methods with an iron concentration that is 3-fold higher in tumors using MT. Conclusions We have developed a method that allows a semi-quantitative evaluation of targeting efficiency in tumors, which could be applied to different T 2 contrast agents.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Biochemistry, Molecular Biology</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival</subject><subject>Colon</subject><subject>Colonic Neoplasms - diagnostic imaging</subject><subject>Colorectal cancer</subject><subject>Contrast agents</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Efficiency</subject><subject>Evaluation</subject><subject>Female</subject><subject>Image contrast</subject><subject>Imaging</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Liposomes</subject><subject>Liver - metabolism</subject><subject>Magnetic permeability</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetics</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Magnetite Nanoparticles - ultrastructure</subject><subject>Medical imaging</subject><subject>Medical innovations</subject><subject>Medicine</subject><subject>Medicine &amp; 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The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI). Procedures Dynamic susceptibility contrast MRI was applied to assess the bloodstream circulation time. A novel semi-quantitative method called % I 0.25 , based on the intensity distribution in T 2 * -weighted MRI images was developed to compare the accumulation of T 2 contrast agent in tumors with or without MT. To evaluate the efficiency of magnetic targeting, the percentage of pixels under the intensity value I 0.25 ( I 0.25  = 0.25( I max  −  I min )) was calculated on the intensity distribution histogram. Results This innovative method of processing MRI images showed the MT efficiency by a % I 0.25 that was significantly higher in tumors using MT compared to passive accumulation, from 15.3 to 28.6 %. 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subjects Accumulation
Animals
Biochemistry, Molecular Biology
Cancer
Cell Line, Tumor
Cell Survival
Colon
Colonic Neoplasms - diagnostic imaging
Colorectal cancer
Contrast agents
Drug delivery
Drug delivery systems
Efficiency
Evaluation
Female
Image contrast
Imaging
Iron
Life Sciences
Liposomes
Liver - metabolism
Magnetic permeability
Magnetic Resonance Imaging
Magnetics
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - ultrastructure
Medical imaging
Medical innovations
Medicine
Medicine & Public Health
Mice
Mice, Inbred BALB C
NIH 3T3 Cells
NMR
Nuclear magnetic resonance
Quantitative analysis
Radiology
Research Article
Tumors
title In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI
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