Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria

[Display omitted] A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 μM) without toxic effec...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2018-01, Vol.28 (2), p.155-159
Main Authors: Sall, C., Ayé, M., Bottzeck, O., Praud, A., Blache, Y.
Format: Article
Language:English
Subjects:
1,3 Cycloadditions
Anti-biofilm
Bacteria
Chemical Sciences
Click chemistry
Material chemistry
Polymers
Triazole
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Summary:[Display omitted] A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 μM) without toxic effect on bacterial growth even at high concentrations(100 μM).
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2017.11.039