Pulmonary arterial systolic pressure and susceptibility to high altitude pulmonary edema

Highlights ► Pulmonary arterial hypertension plays a major role in high altitude pulmonary edema. ► We measured pulmonary systolic pressure in susceptible and resistant subjects to HAPE. ► No overlap in pulmonary systolic pressure was observed between the 2 groups. ► Pulmonary systolic pressure duri...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2011-12, Vol.179 (2), p.294-299
Main Authors: Mounier, Rémi, Amonchot, Aimé, Caillot, Nicolas, Gladine, Cécile, Citron, Bernard, Bedu, Mario, Chirico, Erica, Coudert, Jean, Pialoux, Vincent
Format: Article
Language:English
Subjects:
Adult
Altitude pulmonary disease
Altitude Sickness - metabolism
Altitude Sickness - physiopathology
Biological and medical sciences
Blood Pressure - physiology
Disease Susceptibility - metabolism
Disease Susceptibility - physiopathology
Echocardiography
Echocardiography, Doppler
Enzyme-Linked Immunosorbent Assay
Exercise
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypertension, Pulmonary - metabolism
Hypertension, Pulmonary - physiopathology
Hypoxia
Hypoxia - physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis
Life Sciences
Male
Malondialdehyde - blood
Medical Education
Middle Aged
Nitrates - blood
Nitrites - blood
Pulmonary Artery - physiology
Pulmonary/Respiratory
RNA, Messenger - analysis
Vascular Endothelial Growth Factor A - blood
Vertebrates: respiratory system
Young Adult
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Summary:Highlights ► Pulmonary arterial hypertension plays a major role in high altitude pulmonary edema. ► We measured pulmonary systolic pressure in susceptible and resistant subjects to HAPE. ► No overlap in pulmonary systolic pressure was observed between the 2 groups. ► Pulmonary systolic pressure during a hypoxic exercise challenge may predict HAPE.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2011.09.011