Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients

Presepsin (sCD14-ST) is an emerging biomarker for infection. We hypothesized that presepsin could specifically increase during acute pyelonephritis and correlate with severity. We compared presepsin values in patients with acute pyelonephritis and controls, and we assessed its capacity to predict ba...

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Published in:Clinica chimica acta 2017-01, Vol.464, p.182-188
Main Authors: Claessens, Yann-Erick, Trabattoni, Eloise, Grabar, Sophie, Quinquis, Laurent, Der Sahakian, Guillaume, Anselmo, Marine, Schmidt, Jeannot, de la Coussaye, Jean-Emmanuel, Plaisance, Patrick, Casalino, Enrique, Potel, Gilles, Lecomte, François, Borderie, Didier, Chenevier-Gobeaux, Camille
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Bacteremia - complications
Bacteremia - diagnosis
Biomarkers
Biomarkers - blood
C-reactive protein
Case-Control Studies
Emergency medicine
Female
Human health and pathology
Humans
Life Sciences
Lipopolysaccharide Receptors - blood
Male
Middle Aged
Peptide Fragments - blood
Presepsin
Procalcitonin
Pyelonephritis - blood
Pyelonephritis - complications
Retrospective Studies
Urinary tract infection
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Summary:Presepsin (sCD14-ST) is an emerging biomarker for infection. We hypothesized that presepsin could specifically increase during acute pyelonephritis and correlate with severity. We compared presepsin values in patients with acute pyelonephritis and controls, and we assessed its capacity to predict bacteraemia and admission in patients. In 312 patients with acute pyelonephritis (median age 33years), presepsin concentrations were higher than in controls (476 vs 200ng/L, p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2016.11.036