Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships

Rationale The use of synthetic cathinones as recreational drugs frequently sold in combination has been increasing exponentially. However, the consequences of combining cathinones on the resulting stimulant effects and the pharmacokinetics have been poorly investigated. Objective and methods To stud...

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Published in:Psychopharmacology 2019-03, Vol.236 (3), p.891-901
Main Authors: Benturquia, Nadia, Chevillard, Lucie, Poiré, Christophe, Roussel, Olivier, Cohier, Camille, Declèves, Xavier, Laplanche, Jean-Louis, Etheve-Quelquejeu, Mélanie, Chen, Huixiong, Mégarbane, Bruno
Format: Article
Language:English
Subjects:
Bioavailability
Biomedical and Life Sciences
Biomedicine
Dopamine receptors
Drug testing
Life Sciences
Locomotor activity
Neurons and Cognition
Neurosciences
Original Investigation
Pharmaceutical sciences
Pharmacokinetics
Pharmacology
Pharmacology/Toxicology
Psychiatry
Psychology and behavior
Resveratrol
Rodents
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Summary:Rationale The use of synthetic cathinones as recreational drugs frequently sold in combination has been increasing exponentially. However, the consequences of combining cathinones on the resulting stimulant effects and the pharmacokinetics have been poorly investigated. Objective and methods To study 3,4-methylenedioxypyrovalerone (MDPV; 3 mg/kg) and mephedrone (4-MMC; 30 mg/kg)-induced effects on rat locomotor activity and pharmacokinetics, administered alone or in combination by the intragastric route. The pharmacokinetic parameters were determined using non-compartmental analysis and the relationships between the locomotor activity and drug concentrations using sigmoidal E max modeling. Results Locomotor activity significantly increased during the first hour post-administration with the MDPV/4-MMC combination in comparison to MDPV ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-018-4962-0