The effect of gender and age on kidney cancer survival: Younger age is an independent prognostic factor in women with renal cell carcinoma

Abstract Objective Gender-specific differences in incidence of renal cell carcinoma (RCC) and its outcome have previously been reported. We used age as a surrogate to test whether this might be hormone-related in a large international RCC cohort. Methods and Materials This study included patients tr...

Full description

Saved in:
Bibliographic Details
Published in:Urologic oncology 2014, Vol.32 (1), p.30.e9-30.e13
Main Authors: Rampersaud, Edward N., M.D, Klatte, Tobias, M.D, Bass, Geoffrey, M.D, Patard, Jean-Jacques, M.D, Bensaleh, Karim, M.D, Böhm, Malte, M.D, Allhoff, Ernst P., M.D, Cindolo, Luca, M.D, De La Taille, Alexandre, M.D, Mejean, Arnaud, M.D., Ph.D, Soulie, Michel, M.D, Bellec, Laurent, M.D, Christophe Bernhard, Jean, M.D, Pfister, Christian, MD, Colombel, Marc, M.D, Belldegrun, Arie S., M.D, Pantuck, Allan J., M.D, George, Daniel, M.D
Format: Article
Language:English
Subjects:
Adult
Age Factors
Age groups
Aged
Carcinoma, Renal Cell - epidemiology
Carcinoma, Renal Cell - mortality
Cohort Studies
Epidemiology
Female
Gender
Humans
Kaplan-Meier Estimate
Kidney Neoplasms - epidemiology
Kidney Neoplasms - mortality
Life Sciences
Male
Middle Aged
Prognosis
Proportional Hazards Models
Renal cell carcinoma
Sex Factors
Sex hormones
Treatment Outcome
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective Gender-specific differences in incidence of renal cell carcinoma (RCC) and its outcome have previously been reported. We used age as a surrogate to test whether this might be hormone-related in a large international RCC cohort. Methods and Materials This study included patients treated by nephrectomy at 10 international academic centers. Clinicopathologic features were assessed using chi-square and the Student t -tests. Kaplan-Meier survival estimates and Cox proportional hazards models addressed the effect of gender and age on disease-specific survival. Results Of the 5,654 patients, 3,777 (67%) were men and 1,877 (33%) were women. Generally, women presented at lower T stages ( P
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2012.10.012