Serum S100B Determination in the Management of Pediatric Mild Traumatic Brain Injury

The place of serum S100B measurement in mild traumatic brain injury (mTBI) management is still controversial. Our prospective study aimed to evaluate its utility in the largest child cohort described to date. Children younger than 16 years presenting at a pediatric emergency department within 3 h af...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2012-07, Vol.58 (7), p.1116-1122
Main Authors: BOUVIER, Damien, FOURNIER, Mathilde, DAUPHIN, Jean-Benoît, AMAT, Flore, UGHETTO, Sylvie, LABBE, André, SAPIN, Vincent
Format: Article
Language:English
Subjects:
Adolescent
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers
Biomarkers - blood
Brain damage
Brain Injuries - diagnosis
Brain Injuries - economics
Brain Injuries - physiopathology
Child
Child, Preschool
Clinical medicine
Computed tomography
Consciousness
Emergency medical services
Fundamental and applied biological sciences. Psychology
Head injuries
Head Injuries, Closed - diagnosis
Head Injuries, Closed - economics
Head Injuries, Closed - physiopathology
Headaches
Hospital costs
Hospitalization
Human health and pathology
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Irradiation
Life Sciences
Medical sciences
Molecular biophysics
Molecular weight
Mortality
Nerve Growth Factors - blood
Pediatrics
Prospective Studies
Proteins
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
Serum
Severity of Illness Index
Studies
Tomography, Spiral Computed
Trauma
Vertigo
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Summary:The place of serum S100B measurement in mild traumatic brain injury (mTBI) management is still controversial. Our prospective study aimed to evaluate its utility in the largest child cohort described to date. Children younger than 16 years presenting at a pediatric emergency department within 3 h after TBI were enrolled prospectively for blood sampling to determine serum S100B concentrations. The following information was collected: TBI severity determined by using the Masters classification [1: minimal or Glasgow Coma Scale (GCS) 15, 2: mild or GCS 13-15, and 3: severe or GCS
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2011.180828