Gas-Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO-Catalyzed Aerobic Oxidation of Primary Alcohols

Aerobic oxidation using a combination of copper salts and 2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmen...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-03, Vol.357 (4), p.739-746
Main Authors: Vanoye, Laurent, Pablos, Mertxe, de Bellefon, Claude, Favre-Réguillon, Alain
Format: Article
Language:English
Subjects:
2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO)
6-tetramethylpiperidine N-oxyl (TEMPO)
aerobic oxidation
ALCOHOLS
Catalysis
CATALYSTS
Chemical and Process Engineering
Chemical engineering
Chemical Sciences
Copper
Engineering Sciences
FABRICATION
flow chemistry
Gain
MASS TRANSFER
Microfluidics
Oxidation
Synthesis
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Summary:Aerobic oxidation using a combination of copper salts and 2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover‐limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400925