Gas-Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO-Catalyzed Aerobic Oxidation of Primary Alcohols

Aerobic oxidation using a combination of copper salts and 2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmen...

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Published in:Advanced synthesis & catalysis 2015-03, Vol.357 (4), p.739-746
Main Authors: Vanoye, Laurent, Pablos, Mertxe, de Bellefon, Claude, Favre-Réguillon, Alain
Format: Article
Language:English
Subjects:
2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO)
6-tetramethylpiperidine N-oxyl (TEMPO)
aerobic oxidation
ALCOHOLS
Catalysis
CATALYSTS
Chemical and Process Engineering
Chemical engineering
Chemical Sciences
Copper
Engineering Sciences
FABRICATION
flow chemistry
Gain
MASS TRANSFER
Microfluidics
Oxidation
Synthesis
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cited_by cdi_FETCH-LOGICAL-c6005-6f089f5bf3ea515d594b62d9cbfa2ff8d03850e9ceb06666a3479674b08f82263
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container_end_page 746
container_issue 4
container_start_page 739
container_title Advanced synthesis & catalysis
container_volume 357
creator Vanoye, Laurent
Pablos, Mertxe
de Bellefon, Claude
Favre-Réguillon, Alain
description Aerobic oxidation using a combination of copper salts and 2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover‐limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.
doi_str_mv 10.1002/adsc.201400925
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subjects 2,2,6,6‐tetramethylpiperidine N‐oxyl (TEMPO)
6-tetramethylpiperidine N-oxyl (TEMPO)
aerobic oxidation
ALCOHOLS
Catalysis
CATALYSTS
Chemical and Process Engineering
Chemical engineering
Chemical Sciences
Copper
Engineering Sciences
FABRICATION
flow chemistry
Gain
MASS TRANSFER
Microfluidics
Oxidation
Synthesis
title Gas-Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO-Catalyzed Aerobic Oxidation of Primary Alcohols
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