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Replacing Two Chlorido Ligands by a Bipyridine Ligand in Ruthenium Nitrosyl Complexes with NO‐Release Capabilities: A Comparative Study

[RuII(FT)(bipy)(NO)][PF6]3 [FT is the electron‐rich 4′‐(2‐fluorenyl)‐2,2′:6′,2′′‐terpyridine ligand and bipy is 2,2′‐bipyridine] is synthesized and characterized. It crystallizes in the triclinic P1 space group [a = 9.5362(2) Å, b = 10.3946(4) Å, c = 22.5701(8) Å, α = 94.7400(10)°, β = 94.9400(10)°,...

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Published in:European journal of inorganic chemistry 2017-03, Vol.2017 (11), p.1446-1456
Main Authors: Enriquez‐Cabrera, Alejandro, Sasaki, Isabelle, Bukhanko, Valerii, Tassé, Marine, Mallet‐Ladeira, Sonia, Lacroix, Pascal G., Barba‐Barba, Rodrigo M., Ramos‐Ortiz, Gabriel, Farfán, Norberto, Voitenko, Zoia, Malfant, Isabelle
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cited_by cdi_FETCH-LOGICAL-c3847-46943728f74406a2b8337edc4211967d4eb8f0f353e7e2552c96b47e345080d93
cites cdi_FETCH-LOGICAL-c3847-46943728f74406a2b8337edc4211967d4eb8f0f353e7e2552c96b47e345080d93
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container_issue 11
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container_title European journal of inorganic chemistry
container_volume 2017
creator Enriquez‐Cabrera, Alejandro
Sasaki, Isabelle
Bukhanko, Valerii
Tassé, Marine
Mallet‐Ladeira, Sonia
Lacroix, Pascal G.
Barba‐Barba, Rodrigo M.
Ramos‐Ortiz, Gabriel
Farfán, Norberto
Voitenko, Zoia
Malfant, Isabelle
description [RuII(FT)(bipy)(NO)][PF6]3 [FT is the electron‐rich 4′‐(2‐fluorenyl)‐2,2′:6′,2′′‐terpyridine ligand and bipy is 2,2′‐bipyridine] is synthesized and characterized. It crystallizes in the triclinic P1 space group [a = 9.5362(2) Å, b = 10.3946(4) Å, c = 22.5701(8) Å, α = 94.7400(10)°, β = 94.9400(10)°, γ = 101.0680(10)]. A photochemical study is presented in comparison with that of the parents cis(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6] and trans(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6]. The three derivatives release nitric oxide (·NO) under irradiation at λ = 405 nm with respective quantum yields of 0.06, 0.31, and 0.10. Their two‐photon absorption (TPA) cross‐sections (σTPA) were investigated by the Z‐scan technique on related derivatives in which two hexyl chains were introduced to improve their solubility while their spectroscopic properties remained almost unaffected. The resulting σTPA values of 100 GM at λ = 800 nm are in the window of transparency for human tissues, and the bipyridine‐based complex exhibits a slight tendency for higher efficiency. The replacement of the [RuII(Cl)2(NO)] core by [RuII(bipy)(NO)] provides a much simpler synthesis, and the TPA‐induced ·NO‐release capabilities are in the same range of magnitude. Therefore, it is envisioned that ·NO donors of greater complexity with several metal centers could be investigated in future. A ruthenium(II) nitrosyl complex with terpyridine and bipyridine ligands releases biologically active NO radicals with a quantum yield of 0.06 under two‐photon excitation at λ = 800 nm, which is in the therapeutic window of human tissues, and its two‐photon cross‐section is 108 GM.
doi_str_mv 10.1002/ejic.201601387
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It crystallizes in the triclinic P1 space group [a = 9.5362(2) Å, b = 10.3946(4) Å, c = 22.5701(8) Å, α = 94.7400(10)°, β = 94.9400(10)°, γ = 101.0680(10)]. A photochemical study is presented in comparison with that of the parents cis(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6] and trans(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6]. The three derivatives release nitric oxide (·NO) under irradiation at λ = 405 nm with respective quantum yields of 0.06, 0.31, and 0.10. Their two‐photon absorption (TPA) cross‐sections (σTPA) were investigated by the Z‐scan technique on related derivatives in which two hexyl chains were introduced to improve their solubility while their spectroscopic properties remained almost unaffected. The resulting σTPA values of 100 GM at λ = 800 nm are in the window of transparency for human tissues, and the bipyridine‐based complex exhibits a slight tendency for higher efficiency. The replacement of the [RuII(Cl)2(NO)] core by [RuII(bipy)(NO)] provides a much simpler synthesis, and the TPA‐induced ·NO‐release capabilities are in the same range of magnitude. Therefore, it is envisioned that ·NO donors of greater complexity with several metal centers could be investigated in future. 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It crystallizes in the triclinic P1 space group [a = 9.5362(2) Å, b = 10.3946(4) Å, c = 22.5701(8) Å, α = 94.7400(10)°, β = 94.9400(10)°, γ = 101.0680(10)]. A photochemical study is presented in comparison with that of the parents cis(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6] and trans(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6]. The three derivatives release nitric oxide (·NO) under irradiation at λ = 405 nm with respective quantum yields of 0.06, 0.31, and 0.10. Their two‐photon absorption (TPA) cross‐sections (σTPA) were investigated by the Z‐scan technique on related derivatives in which two hexyl chains were introduced to improve their solubility while their spectroscopic properties remained almost unaffected. The resulting σTPA values of 100 GM at λ = 800 nm are in the window of transparency for human tissues, and the bipyridine‐based complex exhibits a slight tendency for higher efficiency. 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It crystallizes in the triclinic P1 space group [a = 9.5362(2) Å, b = 10.3946(4) Å, c = 22.5701(8) Å, α = 94.7400(10)°, β = 94.9400(10)°, γ = 101.0680(10)]. A photochemical study is presented in comparison with that of the parents cis(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6] and trans(Cl,Cl)‐[RuII(FT)Cl2(NO)][PF6]. The three derivatives release nitric oxide (·NO) under irradiation at λ = 405 nm with respective quantum yields of 0.06, 0.31, and 0.10. Their two‐photon absorption (TPA) cross‐sections (σTPA) were investigated by the Z‐scan technique on related derivatives in which two hexyl chains were introduced to improve their solubility while their spectroscopic properties remained almost unaffected. The resulting σTPA values of 100 GM at λ = 800 nm are in the window of transparency for human tissues, and the bipyridine‐based complex exhibits a slight tendency for higher efficiency. The replacement of the [RuII(Cl)2(NO)] core by [RuII(bipy)(NO)] provides a much simpler synthesis, and the TPA‐induced ·NO‐release capabilities are in the same range of magnitude. Therefore, it is envisioned that ·NO donors of greater complexity with several metal centers could be investigated in future. A ruthenium(II) nitrosyl complex with terpyridine and bipyridine ligands releases biologically active NO radicals with a quantum yield of 0.06 under two‐photon excitation at λ = 800 nm, which is in the therapeutic window of human tissues, and its two‐photon cross‐section is 108 GM.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ejic.201601387</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5676-6924</orcidid><orcidid>https://orcid.org/0000-0001-9025-735X</orcidid><orcidid>https://orcid.org/0000-0001-5295-1025</orcidid><orcidid>https://orcid.org/0000-0002-1185-2124</orcidid><orcidid>https://orcid.org/0009-0004-2446-6697</orcidid></addata></record>
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ispartof European journal of inorganic chemistry, 2017-03, Vol.2017 (11), p.1446-1456
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source Wiley-Blackwell Read & Publish Collection
subjects Chemical Sciences
Coordination chemistry
Cross sections
Density functional calculations
Derivatives
Efficiency
Human tissues
Ligands
Nitrogen oxides
Nitrosyls
Photochemistry
Pyridines
Ruthenium
Synthesis
Two‐photon absorption
title Replacing Two Chlorido Ligands by a Bipyridine Ligand in Ruthenium Nitrosyl Complexes with NO‐Release Capabilities: A Comparative Study
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