Characterization of different vitamin E carriers intended for pulmonary drug delivery

[Display omitted] The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. Liquid dispersions encapsulating vitamin E (liposomes, micelles, nano-emulsion, and solid lipid particles) w...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-08, Vol.471 (1-2), p.385-390
Main Authors: Laouini, A., Andrieu, V., Vecellio, L., Fessi, H., Charcosset, C.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols
Antioxidants - administration & dosage
Antioxidants - pharmacokinetics
Chemical and Process Engineering
Drug Carriers - chemistry
Drug-carrier
Emulsions
Engineering Sciences
Life Sciences
Lipids - chemistry
Liposomes
Lung - metabolism
Lung deposit
Micelles
Models, Biological
Nanoparticles - chemistry
Nebulizers and Vaporizers
Particle Size
Pharmaceutical sciences
Pulmonary administration
Surface Properties
Vitamin E - administration & dosage
Vitamin E - pharmacokinetics
Vitamin E encapsulation
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Summary:[Display omitted] The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. Liquid dispersions encapsulating vitamin E (liposomes, micelles, nano-emulsion, and solid lipid particles) were prepared using various methods based on membrane contactor. The dispersions were nebulized and aerodynamic characteristics of the generated aerosols were assessed using two different methods: laser light scattering and cascade impaction. When the laser diffraction technique was used, results showed that fine particle fractions (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.05.062