Drug carriers in osteoporosis: Preparation, drug encapsulation and applications

Carriers are largely used to enhance therapy efficiency via the encapsulation of active molecules. The encapsulation enhances the stability of drug molecules, improves the targeting properties and prolongs pharmacological activity via continuous local release of active molecules. The aim of this rev...

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-03, Vol.445 (1-2), p.181-195
Main Authors: Miladi, K., Sfar, S., Fessi, H., Elaissari, A.
Format: Article
Language:English
Subjects:
Animals
Capsules
Carriers
Chemical and Process Engineering
drug carriers
Drug Carriers - chemistry
Drug Carriers - therapeutic use
Drug Compounding
Drug release
drugs
Encapsulation
Engineering Sciences
Humans
In vitro
In vivo
Life Sciences
Low bioavailability
Osteoporosis
Osteoporosis - drug therapy
Pharmaceutical sciences
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Summary:Carriers are largely used to enhance therapy efficiency via the encapsulation of active molecules. The encapsulation enhances the stability of drug molecules, improves the targeting properties and prolongs pharmacological activity via continuous local release of active molecules. The aim of this review is to report the carrier systems used in osteoporosis therapy. This state of the art research has mainly focused on describing all types of carriers used in this area, their elaboration and properties, the drug characteristics used in such specific application, and drug release and efficiency. In this field, various processes have been used in order to obtain well-defined capsules, spheres and more complex carriers. In this exhaustive review, each process is described, illustrated and discussed.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2013.01.031