Impact of deep brain stimulation on pharyngo‐esophageal motility: a randomized cross‐over study

• Published in: Neurogastroenterology and motility 2015-09, Vol.27 (9), p.1214-1222
• Main Authors: Derrey, S., Chastan, N., Maltete, D., Verin, E., Dechelotte, P., Lefaucheur, R., Proust, F., Freger, P., Leroi, A. M., Weber, J., Gourcerol, G.
• Format: Article
• Language: English
• Subjects: Aged; Cross-Over Studies; Deep Brain Stimulation; Esophagus - physiopathology; Female; Gastrointestinal Motility; gut motility; high resolution manometry; Human health and pathology; Humans; Life Sciences; Male; Manometry; Middle Aged; Neurons and Cognition; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Pharynx - physiopathology; subthalamic nucleus; Subthalamic Nucleus - physiopathology; Tissues and Organs; Treatment Outcome
• ISSN: 1350-1925; 1365-2982
• DOI: 10.1111/nmo.12607

Background Bilateral subthalamic nucleus (STN) stimulation is used to alleviate Parkinson's disease (PD) motor symptoms. Recently, it has been shown that this therapeutic also increased gut cholinergic contractions. We therefore investigated the effect of STN stimulation on esophageal motility in an interventional randomized study. Methods Sixteen humans PD patients (4 women, 12 men; age: 62.4 ± 9.3‐years old) who underwent STN stimulation for at least 6 months were randomly evaluated with either stimulator turned OFF then ON, or inversely. Esophageal high resolution manometry was performed at the end of each ON and OFF period, with a 5 min resting period followed by ten swallows of 5 mL. Key Results During the ON, an increase in the distal contractility index was found (OFF: 1750 ± 629 vs ON: 2171 ± 755 mmHg/cm/s; p = 0.03), with no difference in the distal front velocity. A decrease in the integrative relaxation pressure of the lower esophageal sphincter (LES) was noted (OFF: 11.1 ± 1.8 mmHg vs ON: 7.2 ± 1.8 mmHg; p