The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions

Highlights ► 26RFa is a novel vertebrate RFamide peptide. ► 26RFa is the endogenous ligand of the human orphan receptor GPR103. ► 26RFa stimulates food intake in mammals, birds and fish. ► 26RFa up-regulates the gondatropic axis in mammals and fish. ► 26RFa also regulates steroidogenesis, bone forma...

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Bibliographic Details
Published in:Frontiers in neuroendocrinology 2011-10, Vol.32 (4), p.387-397
Main Authors: Chartrel, Nicolas, Alonzeau, Jessy, Alexandre, David, Jeandel, Lydie, Alvear-Perez, Rodrigo, Leprince, Jérôme, Boutin, Jean, Vaudry, Hubert, Anouar, Youssef, Llorens-Cortes, Catherine
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cell Behavior
Cellular Biology
Chemical Sciences
Cyclic AMP
Endocrinology & Metabolism
Evolution
Feeding behavior
G protein-coupled receptor
Ghrelin
Humans
Hypothalamo-pituitary-gonadal axis
Hypothalamus
Life Sciences
Ligands
Medicinal Chemistry
Models, Biological
Molecular Sequence Data
Neurobiology
Neuroendocrine Cells
Neuroendocrine Cells - drug effects
Neuroendocrine Cells - metabolism
Neuroendocrine Cells - physiology
Neurons and Cognition
Neuropeptide
Neuropeptides
Neuropeptides - genetics
Neuropeptides - metabolism
Neuropeptides - pharmacology
Neuropeptides - physiology
Peptide Hormones
Pharmaceutical sciences
Pharmacology
Pituitary Gland
Protein Binding
Receptors, G-Protein-Coupled
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
RFamide peptide
Tissue Distribution
Transfection
Vertebrate
Vertebrates
Vertebrates - genetics
Vertebrates - metabolism
Vertebrates - physiology
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Summary:Highlights ► 26RFa is a novel vertebrate RFamide peptide. ► 26RFa is the endogenous ligand of the human orphan receptor GPR103. ► 26RFa stimulates food intake in mammals, birds and fish. ► 26RFa up-regulates the gondatropic axis in mammals and fish. ► 26RFa also regulates steroidogenesis, bone formation and nociceptive transmission.
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2011.04.001