Central and peripheral cardiovascular, ventilatory, and motor effects of trout urotensin-II in the trout

Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very littl...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2008-05, Vol.29 (5), p.830-837
Main Authors: Le Mével, Jean-Claude, Lancien, Frédéric, Mimassi, Nagi, Leprince, Jérôme, Conlon, J. Michael, Vaudry, Hubert
Format: Article
Language:English
Subjects:
Animals
Blood pressure
Brain
Cardiovascular System
Cardiovascular System - drug effects
Cell Behavior
Cellular Biology
Central Nervous System
Central Nervous System - anatomy & histology
Central Nervous System - drug effects
Central Nervous System - physiology
Chemical Sciences
Heart rate
Intra-arterial injection
Intracerebroventricular injection
Life Sciences
Locomotion
Medicinal Chemistry
Motor Activity
Motor Activity - drug effects
Neurobiology
Neurons and Cognition
Neuropeptides
Oncorhynchus mykiss
Oncorhynchus mykiss - physiology
Pharmaceutical sciences
Pharmacology
Respiratory System
Respiratory System - drug effects
Urotensins
Urotensins - pharmacology
Ventilation
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Summary:Urotensin-II (U-II) was originally considered to be exclusively the product of the caudal neurosecretory system (CNSS) of teleost fish, but it has now been demonstrated that U-II is widely expressed in peripheral tissues and nervous structures of species from lampreys to mammals. However, very little is known regarding the physiological effects of this peptide in its species of origin. In the present review, we summarize the most significant results relating to the cardiovascular, ventilatory, and motor effects of centrally and peripherally administered synthetic trout U-II in our experimental animal model, the unanesthetized trout Oncorhynchus mykiss. In addition, we compare the actions of U-II with those of other neurohormonal peptides, particularly with the actions of urotensin-I, a 41-amino acid residue peptide paralogous to corticotropin-releasing hormone that is co-localized with U-II within neurons of the CNSS.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2007.06.020