Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts

Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain. We studied the effects of UII on isolated heart preparations of Chinook salmon and Sprague–Dawley rats. Native rat UII...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-12, Vol.27 (12), p.3261-3268
Main Authors: Prosser, H.C.G., Leprince, J., Vaudry, H., Richards, A.M., Forster, M.E., Pemberton, C.J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Behavior
Cellular Biology
Chemical Sciences
Coronary Vessels
Coronary Vessels - metabolism
Fundamental and applied biological sciences. Psychology
Isolated rat heart
Life Sciences
Male
Medicinal Chemistry
Myocardium
Myocardium - metabolism
Neurobiology
Neurons and Cognition
Peptide Hormones
Peptide Hormones - antagonists & inhibitors
Peptide Hormones - physiology
Pharmaceutical sciences
Pharmacology
Rats
Rats, Sprague-Dawley
Salmon
Salmon coronary arteries
Urotensin II
Urotensins
Urotensins - antagonists & inhibitors
Urotensins - physiology
URP
Vasodilation
Vertebrates: endocrinology
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Summary:Urotensin II (UII) was first discovered in the urophyses of goby fish and later identified in mammals, while urotensin II-related peptide (URP) was recently isolated from rat brain. We studied the effects of UII on isolated heart preparations of Chinook salmon and Sprague–Dawley rats. Native rat UII caused potent and sustained, dose-dependent dilation of the coronary arteries in the rat, whereas non-native UII (human and trout UII) showed attenuated vasodilation. Rat URP dilated rat coronary arteries, with 10-fold less potency compared with rUII. In salmon, native trout UII caused sustained dilation of the coronary arteries, while rat UII and URP caused significant constriction. Nω-nitro- l -arginine methyl ( l-NAME) and indomethacin significantly attenuated the URP and rat UII-induced vasodilation in the rat heart. We conclude that UII is a coronary vasodilator, an action that is species form specific. We also provide the first evidence for cardiac actions of URP, possibly via mechanisms common with UII.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2006.09.012