Nonlinear Rheology in a Model Biological Tissue

The rheological response of dense active matter is a topic of fundamental importance for many processes in nature such as the mechanics of biological tissues. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a particle-based m...

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Bibliographic Details
Published in:Physical review letters 2017-04, Vol.118 (15), p.158105-158105, Article 158105
Main Authors: Matoz-Fernandez, D A, Agoritsas, Elisabeth, Barrat, Jean-Louis, Bertin, Eric, Martens, Kirsten
Format: Article
Language:English
Subjects:
Condensed Matter
Crossovers
Materials Science
Mechanical properties
Noise
Nonlinearity
Physics
Rheology
Shear rate
Stresses
Tissues (biology)
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Summary:The rheological response of dense active matter is a topic of fundamental importance for many processes in nature such as the mechanics of biological tissues. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a particle-based model featuring random apoptosis and environment-dependent division rates, we evidence a crossover from linear flow to a shear-thinning regime with an increasing shear rate. To rationalize this nonlinear flow we derive a theoretical mean-field scenario that accounts for the interplay of mechanical and active noise in local stresses. These noises are, respectively, generated by the elastic response of the cell matrix to cell rearrangements and by the internal activity.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.118.158105