Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chi...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1998-07, Vol.184 (1-2), p.125-140
Main Authors: Schlattner, U, Forstner, M, Eder, M, Stachowiak, O, Fritz-Wolf, K, Wallimann, T
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Binding Sites - physiology
Chickens
Creatine - metabolism
Creatine Kinase - chemistry
Crystallography, X-Ray
Life Sciences
Mitochondria - enzymology
Models, Molecular
Molecular Sequence Data
Phosphocreatine - metabolism
Protein Conformation
Proteins
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Summary:Mitochondrial creatine kinase (Mi-CK) is a central enzyme in energy metabolism of tissues with high and fluctuating energy requirements. In this review, recent progress in the functional and structural characterization of Mi-CK is summarized with special emphasis on the solved X-ray structure of chicken Mib-CK octamer (Fritz-Wolf et al., Nature 381, 341-345, 1996). The new results are discussed in a historical context and related to the characteristics of CK isoforms as known from a large number of biophysical and biochemical studies. Finally, two hypothetical functional aspects of the Mi-CK structure are proposed: (i) putative membrane binding motifs at the top and bottom faces of the octamer and (ii) a possible functional role of the central 20 A channel.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1006851330913