Influence of a high-glucose diet on the sensitivity of Caenorhabditis elegans towards Escherichia coli and Staphylococcus aureus strains

It was recently observed that a glucose-enriched diet activates the insulin-like pathway in Caenorhabditis elegans, resulting in an inhibition of the FOXO transcription factor DAF-16. Because this signalling pathway is highly conserved from invertebrates to mammals and DAF-16 is a key player in inna...

Full description

Saved in:
Bibliographic Details
Published in:Microbes and infection 2013-07, Vol.15 (8-9), p.540-549
Main Authors: Lavigne, Jean-Philippe, Audibert, Sylvain, Molinari, Nicolas, O’Callaghan, David, Keriel, Anne
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Caenorhabditis elegans
Caenorhabditis elegans - immunology
Caenorhabditis elegans - microbiology
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - metabolism
DAF-16
Diabetes Complications - immunology
Diabetes mellitus
Diet - methods
Disease Models, Animal
Disease Susceptibility
Escherichia coli
Escherichia coli Infections - immunology
Forkhead Transcription Factors
Gene Expression Regulation
Glucose - metabolism
Human health and pathology
Infectious diseases
Life Sciences
Microbiology and Parasitology
Nematoda
Staphylococcal Infections - immunology
Staphylococcus aureus
Survival Analysis
Transcription Factors - metabolism
Virology
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It was recently observed that a glucose-enriched diet activates the insulin-like pathway in Caenorhabditis elegans, resulting in an inhibition of the FOXO transcription factor DAF-16. Because this signalling pathway is highly conserved from invertebrates to mammals and DAF-16 is a key player in innate immunity, we wondered whether a high-glucose diet, resembling the hyperglycaemic conditions in diabetic patients, would affect the susceptibility of C. elegans to bacterial pathogens isolated from different clinical situations (urinary tract or diabetic foot infections). We confirmed previous reports showing that such a diet decreases the lifespan of C. elegans fed with an avirulent Escherichia coli strain. However, glucose-fed nematodes appeared to be more resistant to most clinical isolates tested, showing that this invertebrate model does not mimic infections encountered in human diabetes, where patients show increased susceptibility to bacterial infections. This study also suggests that modulation of innate immunity in C. elegans, upon activation of the IGF1/insulin-like pathway by glucose, is not exclusively mediated by DAF-16, but also involves an additional factor that requires DAF-16 activity.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2013.04.006