Schema cells in the macaque hippocampus

Concept cells in the human hippocampus encode the meaning conveyed by stimuli over their perceptual aspects. Here we investigate whether analogous cells in the macaque can form conceptual schemas of spatial environments. Each day, monkeys were presented with a familiar and a novel virtual maze, shar...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2019-02, Vol.363 (6427), p.635-639
Main Authors: Baraduc, P, Duhamel, J-R, Wirth, S
Format: Article
Language:English
Subjects:
Animal cognition
Animals
Brain
Cognitive science
Environment
Environments
Hippocampus
Landmarks
Landscape
Monkeys
Neurons
Neuroscience
Primates
Reinforcement
Virtual environments
Visual stimuli
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Summary:Concept cells in the human hippocampus encode the meaning conveyed by stimuli over their perceptual aspects. Here we investigate whether analogous cells in the macaque can form conceptual schemas of spatial environments. Each day, monkeys were presented with a familiar and a novel virtual maze, sharing a common schema but differing by surface features (landmarks). In both environments, animals searched for a hidden reward goal only defined in relation to landmarks. With learning, many neurons developed a firing map integrating goal-centered and task-related information of the novel maze that matched that for the familiar maze. Thus, these hippocampal cells abstract the spatial concepts from the superficial details of the environment and encode space into a schema-like representation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aav5404