Graphene based porous coatings with antibacterial and antithrombogenous function—Materials and design

The studies considered graphene-based biomaterials dedicated for cardiovascular therapy. Reduced graphene oxide flakes were introduced into the porous structure of the polyelectro-lyte based coatings. TEM analysis showed thepresenceofgrapheneflakes arrangedparallelto the substrate surface, firmly co...

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Bibliographic Details
Published in:Archives of Civil and Mechanical Engineering 2014-08, Vol.14 (4), p.540-549
Main Authors: Major, R., Sanak, M., Mzyk, A., Lipinska, L., Kot, M., Lacki, P., Bruckert, F., Major, B.
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Biological properties
Biomedical materials
Blood
Chemical Sciences
Civil Engineering
Coagulation
Coatings
E coli
Engineering
Finite element method
Flakes
Graphene
Material chemistry
Material properties
Mechanical analysis
Mechanical Engineering
Original Research Article
Structural Materials
Substrates
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Summary:The studies considered graphene-based biomaterials dedicated for cardiovascular therapy. Reduced graphene oxide flakes were introduced into the porous structure of the polyelectro-lyte based coatings. TEM analysis showed thepresenceofgrapheneflakes arrangedparallelto the substrate surface, firmly connected to the porous coating. Biomaterials were subjectedtoa comprehensive diagnosis ofthe biological and material properties. The material behavior was simulated using finite element method. The coatings were deposited using layer by layer method. Mechanical analysis was done using Berkovich indenter geometry. They confirmed theoretical FEA based calculations, it was observed the coating stiffness incensement under the influence of introduced particles of graphene. The endanger of the bacteriology film formation was verified based on the E-coli and Staphylo coccus bacteria. Blood-material interaction was examined in the dynamic flow conditions. Bacteriological analysis showed reduced presence of bacteria after contact with the surface with introduced graphene flakes. Dynamic analyzes on blood showed high activation of the coagulation, strong platelets consumption and a strong immune response. It is caused by sharp edge of the single plane of the graphene flake.
ISSN:1644-9665
2083-3318
DOI:10.1016/j.acme.2014.04.012