Regulat-INGs in tumors and diseases: Focus on ncRNAs

ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully eluci...

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Bibliographic Details
Published in:Cancer letters 2019-04, Vol.447, p.66-74
Main Authors: Gournay, Marjorie, Paineau, Mathieu, Archambeau, Jérôme, Pedeux, Rémy
Format: Article
Language:English
Subjects:
3' Untranslated regions
Animals
Apoptosis
Biochemistry, Molecular Biology
Biomarkers
Brain tumors
Cancer
Caretaker
Cell cycle
Disease - genetics
Diseases
Gastric cancer
Gatekeeper
Gene expression
Gene Expression Regulation - genetics
Gene regulation
Genes
Genomics
Homeostasis
Humans
Inhibitor of Growth Protein 1 - genetics
Life Sciences
Liver
lncRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Mutation
Neoplasms - genetics
Nucleotide sequence
Ovarian cancer
Pancreas
Post-transcription
Proteins
RNA, Messenger - genetics
RNA, Untranslated - genetics
Stem cells
Tumor suppressor genes
Tumorigenesis
Tumors
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Summary:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvement of non-coding RNAs (ncRNAs) and in particular microRNAs (miRNAs) in post-transcriptional gene regulation is well established. miRNAs are short sequences (18–25 nucleotides) that can bind to the 3 ′UTR sequence of the targeted messenger RNA (mRNA), leading to its degradation or translational repression. Interactions between the ING family and miRNAs have been described in some cancers but also in other diseases. The involvement of miRNAs in ING family regulation opens up new fields of investigation, particularly for targeted therapies. In this review, we will summarize the regulatory mechanisms at the RNA and protein level of the ING family and focus on the interactions with ncRNAs. •INGs are tumor suppressor genes playing a crucial role in cell homeostasis.•Multiple mechanisms may be involved in INGs loss or downregulation.•INGs regulation is still unclear and can involve ncRNAs.•ncRNAs may play an important role in cancer and other disease notably through INGs regulation.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2019.01.006