Regulat-INGs in tumors and diseases: Focus on ncRNAs

• Published in: Cancer letters 2019-04, Vol.447, p.66-74
• Main Authors: Gournay, Marjorie, Paineau, Mathieu, Archambeau, Jérôme, Pedeux, Rémy
• Format: Article
• Language: English
• Subjects: 3' Untranslated regions; Animals; Apoptosis; Biochemistry, Molecular Biology; Biomarkers; Brain tumors; Cancer; Caretaker; Cell cycle; Disease - genetics; Diseases; Gastric cancer; Gatekeeper; Gene expression; Gene Expression Regulation - genetics; Gene regulation; Genes; Genomics; Homeostasis; Humans; Inhibitor of Growth Protein 1 - genetics; Life Sciences; Liver; lncRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Mutation; Neoplasms - genetics; Nucleotide sequence; Ovarian cancer; Pancreas; Post-transcription; Proteins; RNA, Messenger - genetics; RNA, Untranslated - genetics; Stem cells; Tumor suppressor genes; Tumorigenesis; Tumors
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2019.01.006

ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvement of non-coding RNAs (ncRNAs) and in particular microRNAs (miRNAs) in post-transcriptional gene regulation is well established. miRNAs are short sequences (18–25 nucleotides) that can bind to the 3 ′UTR sequence of the targeted messenger RNA (mRNA), leading to its degradation or translational repression. Interactions between the ING family and miRNAs have been described in some cancers but also in other diseases. The involvement of miRNAs in ING family regulation opens up new fields of investigation, particularly for targeted therapies. In this review, we will summarize the regulatory mechanisms at the RNA and protein level of the ING family and focus on the interactions with ncRNAs. •INGs are tumor suppressor genes playing a crucial role in cell homeostasis.•Multiple mechanisms may be involved in INGs loss or downregulation.•INGs regulation is still unclear and can involve ncRNAs.•ncRNAs may play an important role in cancer and other disease notably through INGs regulation.