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Interference of cationic polymeric nanoparticles with clinical chemistry tests—Clinical relevance

[Display omitted] The development of medical nanosystems requires knowledge of their behavior in vivo. Clinical chemistry tests are widely used to estimate the systemic toxicity of nanoparticles. In this paper we have explored the impact of small positively charged nanoparticles–poly(amidoamine), ph...

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Published in:International journal of pharmaceutics 2014-10, Vol.473 (1-2), p.599-606
Main Authors: Shcharbin, Dzmitry, Shcharbina, Natallia, Milowska, Katarzyna, de la Mata, Francisco Javier, Muñoz-Fernandez, Maria Angeles, Mignani, Serge, Gomez-Ramirez, Rafael, Majoral, Jean-Pierre, Bryszewska, Maria
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cited_by cdi_FETCH-LOGICAL-c539t-4a9a1af53b9d383df3b2f676005f9d10f43c75b547f64b95115549f1f9c1ba9b3
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container_title International journal of pharmaceutics
container_volume 473
creator Shcharbin, Dzmitry
Shcharbina, Natallia
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de la Mata, Francisco Javier
Muñoz-Fernandez, Maria Angeles
Mignani, Serge
Gomez-Ramirez, Rafael
Majoral, Jean-Pierre
Bryszewska, Maria
description [Display omitted] The development of medical nanosystems requires knowledge of their behavior in vivo. Clinical chemistry tests are widely used to estimate the systemic toxicity of nanoparticles. In this paper we have explored the impact of small positively charged nanoparticles–poly(amidoamine), phosphorous and carbosilane dendrimers – on biochemical parameters of standardized serum in vitro. All the dendrimers could shift the main biochemical parameters. Thus, in the case of patients having the normal, but ‘boundary’, values of biochemical parameters, nanoparticle-induced changes can be wrongly interpreted as evidence of some dysfunctions (hepatic, renal, etc.). Moreover, the effects of nanoparticles of metals, carbon nanotubes, quantum dots, fullerenes, dendrimers having been sized up to 4000nm and the hundreds of reactive groups, can be significantly higher. Thus, preliminary evaluation of any nanomaterial in vitro is required in clinical chemistry tests before its application in vivo to draw the correct conclusions and benefit animals.
doi_str_mv 10.1016/j.ijpharm.2014.07.054
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subjects Chemical Sciences
Clinical chemistry test
Clinical Chemistry Tests
Coordination chemistry
Dendrimer
Dendrimers - chemistry
Enzyme
Nanoparticle
Nanoparticles - chemistry
Phosphorus - chemistry
Protein
Serum - chemistry
Silanes - chemistry
title Interference of cationic polymeric nanoparticles with clinical chemistry tests—Clinical relevance
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