Flush with a flash: natural three-component antimicrobial combinations based on S -nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite

-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O ˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO ). Since the production of O ˙ can be controlled by enzymes or by visible light, such otherwise harmless components can b...

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Bibliographic Details
Published in:MedChemComm 2018-12, Vol.9 (12), p.1994-1999
Main Authors: Alhasan, Rama, Kharma, Ammar, Nasim, Muhammad Jawad, Abdin, Ahmad Yaman, Bonetti, Justine, Giummelly, Philippe, Ejike, Chukwunonso E C C, Leroy, Pierre, Gaucher, Caroline, Jacob, Claus
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antioxidants
Biochemistry
Biochemistry, Molecular Biology
Cascade chemical reactions
Cell Behavior
Cellular Biology
Life Sciences
Peroxynitrite
Subcellular Processes
Superoxide
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Summary:-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O ˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO ). Since the production of O ˙ can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.
ISSN:2040-2503
2040-2511
DOI:10.1039/c8md00414e