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General method for the synthesis of substituted phenanthridin-6(5 H)-ones using a KOH-mediated anionic ring closure as the key step
Substituted phenanthridin-6(5 H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodology offers a gen...
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Published in: | Tetrahedron 2010-07, Vol.66 (27), p.5008-5016 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Substituted phenanthridin-6(5
H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodology offers a general and practical route to diversely substituted phenanthridin-6(5
H)-ones.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2010.05.014 |