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General method for the synthesis of substituted phenanthridin-6(5 H)-ones using a KOH-mediated anionic ring closure as the key step

Substituted phenanthridin-6(5 H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodology offers a gen...

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Bibliographic Details
Published in:Tetrahedron 2010-07, Vol.66 (27), p.5008-5016
Main Authors: Dubost, Emmanuelle, Magnelli, Rosa, Cailly, Thomas, Legay, Rémi, Fabis, Frédéric, Rault, Sylvain
Format: Article
Language:English
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Summary:Substituted phenanthridin-6(5 H)-ones were obtained in a two-step procedure involving a Suzuki cross-coupling reaction followed by a KOH-mediated anionic ring closure. The influence of the nature and the position of the substituents on the cyclization step were studied. This methodology offers a general and practical route to diversely substituted phenanthridin-6(5 H)-ones. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2010.05.014