The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

Abstract In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the d...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2017-11, Vol.49 (21), p.4808-4826
Main Authors: Zhao, Qun, Poisson, Thomas, Pannecoucke, Xavier, Besset, Tatiana
Format: Article
Language:English
Subjects:
Chemical Sciences
short review
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Summary:Abstract In recent years, the C–H bond activation field has known very fast expansion offering valuable synthetic tools. Consequently, the quest for new approaches to afford atom- and step-economical processes has driven the scientific community to imagine original strategies. In this context, the direct functionalization of substrates by a transition-metal-catalyzed C–H bond activation using a transient directing group has emerged as a promising approach. This short review focuses on the major progress made in this field to provide to the reader an overview of the recent advances. 1 Introduction 2 From a Historical Point of View 3 Functionalization of Carbonyl Derivatives 4 Functionalization of Amines Derivatives 5 Summary and Outlook
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1590878