Influence of static magnetic field on cadmium toxicity: Study of oxidative stress and DNA damage in rat tissues

In the present study, we investigated the effect of co-exposure to static magnetic field (SMF) and cadmium (Cd) on the biochemical parameters, antioxidant enzymes activity and DNA damage in rat tissues. Animals were treated with cadmium (CdCl 2, 40 mg/L, per os) in drinking water during 4 weeks. Cd...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology 2006-01, Vol.20 (4), p.263-269
Main Authors: Amara, Salem, Abdelmelek, Hafedh, Garrel, Catherine, Guiraud, Pascale, Douki, Thierry, Ravanat, Jean-Luc, Favier, Alain, Sakly, Mohsen, Ben Rhouma, Khémais
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Antioxidants - pharmacology
Cadmium
Cadmium - toxicity
Cadmium Poisoning
Chemical Sciences
DNA Damage
Life Sciences
Magnetics
Male
Oxidative Stress
Rat
Rats
Rats, Wistar
Static magnetic field
Toxicology
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Summary:In the present study, we investigated the effect of co-exposure to static magnetic field (SMF) and cadmium (Cd) on the biochemical parameters, antioxidant enzymes activity and DNA damage in rat tissues. Animals were treated with cadmium (CdCl 2, 40 mg/L, per os) in drinking water during 4 weeks. Cd treatment induced an increase of plasma lactate dehydrogenase (LDH) and transaminases levels. Moreover, Cd treatment increased malondialdehyde (MDA) and 8-oxodGuo levels in rat tissues. However, the antioxidant enzymes activity such as the glutathione peroxidase (GPx), catalase (CAT) and the superoxide dismutase (SOD) were decreased in liver and kidney, while we noted a huge increase of hepatic and renal cadmium content. Interestingly, the combined effect of SMF (128mT, 1 h/day during 30 consecutive days) and Cd (40 mg/L, per os) decreased the GPx and CAT activities in liver compared to cadmium treated group. However, the association between SMF and Cd failed to alter transaminases, MDA and 8-oxodGuo concentration. Cd treatment altered antioxidant enzymes and DNA in liver and kidney of rats. Moreover, SMF associated to Cd disrupt this antioxidant response in liver compared to Cd-treated rats.
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2006.07.002