Preventive Effect of Zinc Against Cadmium-induced Oxidative Stress in the Rat Testis

The aim of this study was to investigate the antioxidant role of zinc (Zn) in the Cd-exposed testes of Wistar rats. Subchronic exposure to Cd (CdCl2, 40 mg/l, per os) for 30 days resulted in a significant reduction in growth rate (-11%) and relative weights of testes (-36%) and seminal vesicles (-80...

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Published in:Journal of Reproduction and Development 2008, Vol.54(2), pp.129-134
Main Authors: AMARA, Salem, ABDELMELEK, Hafedh, GARREL, Catherine, GUIRAUD, Pascale, DOUKI, Thierry, RAVANAT, Jean-Luc, FAVIER, Alain, SAKLY, Mohsen, RHOUMA, Khémais BEN
Format: Article
Language:English
Subjects:
Analytical chemistry
Animals
Antioxidants - metabolism
Cadmium
Cadmium - chemistry
Cadmium - metabolism
Chemical Sciences
DNA - metabolism
Life Sciences
Male
Malondialdehyde - metabolism
Mitochondria - metabolism
Models, Biological
Oxidative Stress
Oxygen - chemistry
Rat
Rats
Spermatogenesis
Superoxide Dismutase - metabolism
Testis - metabolism
Testosterone
Testosterone - metabolism
Toxicology
Zinc
Zinc - chemistry
Zinc - metabolism
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Summary:The aim of this study was to investigate the antioxidant role of zinc (Zn) in the Cd-exposed testes of Wistar rats. Subchronic exposure to Cd (CdCl2, 40 mg/l, per os) for 30 days resulted in a significant reduction in growth rate (-11%) and relative weights of testes (-36%) and seminal vesicles (-80%). Treated rats displayed a decrease in testicular and plasma testosterone levels, respectively (-70%, P
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.18110