Longitudinal study of functional brain network reorganization in clinically isolated syndrome

Background: There is a lack of longitudinal studies exploring the topological organization of functional brain networks at the early stages of multiple sclerosis (MS). Objective: This study aims to assess potential brain functional reorganization at rest in patients with CIS (PwCIS) after 1 year of...

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Bibliographic Details
Published in:Multiple sclerosis 2020-02, Vol.26 (2), p.188-200
Main Authors: Koubiyr, Ismail, Deloire, Mathilde, Besson, Pierre, Coupé, Pierrick, Dulau, Cécile, Pelletier, Jean, Tourdias, Thomas, Audoin, Bertrand, Brochet, Bruno, Ranjeva, Jean-Philippe, Ruet, Aurélie
Format: Article
Language:English
Subjects:
Adult
Bioengineering
Brain - diagnostic imaging
Brain - physiopathology
Brain architecture
Demyelinating Diseases - diagnostic imaging
Demyelinating Diseases - physiopathology
Female
Functional morphology
Humans
Image Interpretation, Computer-Assisted
Imaging
Life Sciences
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Multiple sclerosis
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neuroimaging - methods
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Summary:Background: There is a lack of longitudinal studies exploring the topological organization of functional brain networks at the early stages of multiple sclerosis (MS). Objective: This study aims to assess potential brain functional reorganization at rest in patients with CIS (PwCIS) after 1 year of evolution and to characterize the dynamics of functional brain networks at the early stage of the disease. Methods: We prospectively included 41 PwCIS and 19 matched healthy controls (HCs). They were scanned at baseline and after 1 year. Using graph theory, topological metrics were calculated for each region. Hub disruption index was computed for each metric. Results: Hub disruption indexes of degree and betweenness centrality were negative at baseline in patients (p 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458518813108