Influence of age and osteoporosis on calcaneus trabecular bone structure: a preliminary in vivo MRI study by quantitative texture analysis

Recent developments in high-resolution MR imaging techniques have opened up new perspectives for structural characterization of trabecular bone by non-invasive methods. In this study, 3-D MR imaging was performed on 17 healthy volunteers and 6 osteoporotic patients. Two different MR sequences were u...

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Bibliographic Details
Published in:Magnetic resonance imaging 2004-02, Vol.22 (2), p.237-243
Main Authors: Herlidou, S, Grebe, R, Grados, F, Leuyer, N, Fardellone, P, Meyer, M.-E
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - pathology
Bone structure
Calcaneus
Calcaneus - anatomy & histology
Calcaneus - pathology
Correspondence factorial analysis
Female
Hierarchical classification
Humans
Image Processing, Computer-Assisted - methods
Life Sciences
Magnetic Resonance Imaging - methods
Middle Aged
MRI
Osteoporosis
Osteoporosis, Postmenopausal - diagnosis
Sensitivity and Specificity
Texture analysis
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Summary:Recent developments in high-resolution MR imaging techniques have opened up new perspectives for structural characterization of trabecular bone by non-invasive methods. In this study, 3-D MR imaging was performed on 17 healthy volunteers and 6 osteoporotic patients. Two different MR sequences were used to evaluate the impact on MR acquisition on texture analysis results. Images were analyzed with four automated methods of texture analysis (grey level histogram, cooccurrence, runlength and gradient matrices) enabling quantitative analysis of grey level intensity and distribution within three different regions of interest (ROI). Texture analysis is not very frequently used since the interpretation of the large number of calculated parameters is difficult. We applied multiparametric data analyses such as principal component analysis (CFA) and hierarchical ascending classification (HAC) to determine the relevant parameters to differentiate between three sets of images (healthy young volunteers, healthy postmenopaused and osteoporotic patients). The results suggest that relevant texture information (depending on the ROI localization in the calcaneus) can be extracted from calcaneus MR images to evaluate osteoporosis and age effects on trabecular bone structure if strictly the same acquisition sequences are used for all patients' examination.
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2003.07.007