Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C 60 (OH) x and Gd@C 60 [C(COOH 2 )] 10

A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomen...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2005-07, Vol.127 (26), p.9368-9369
Main Authors: Laus, Sabrina, Sitharaman, Balaji, Tóth, Éva, Bolskar, Robert D., Helm, Lothar, Asokan, Subashini, Wong, Michael S., Wilson, Lon J., Merbach, André E.
Format: Article
Language:English
Subjects:
Life Sciences
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Summary:A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja052388+