High Relaxivity for Monomeric Gd(DOTA)-Based MRI Contrast Agents, Thanks to Micellar Self-Organization

A new amphiphilic GdIII chelate, which is capable of forming micelles in aqueous solution (see diagram), has been synthesized. Due to this self‐aggregation, the compound has a long rotational correlation time and, consequently, has high proton relaxivities that thus far have only been obtained with...

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Bibliographic Details
Published in:Chemistry : a European journal 1999-10, Vol.5 (10), p.2977-2983
Main Authors: André, João P., Tóth, Éva, Fischer, Holger, Seelig, Anna, Mäcke, Helmut R., Merbach, André E.
Format: Article
Language:English
Subjects:
Amphiphiles
Contrast agents
Gadolinium complexes
Life Sciences
Micelles
MRI
Online Access:Get full text
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Summary:A new amphiphilic GdIII chelate, which is capable of forming micelles in aqueous solution (see diagram), has been synthesized. Due to this self‐aggregation, the compound has a long rotational correlation time and, consequently, has high proton relaxivities that thus far have only been obtained with macromolecular complexes.
ISSN:0947-6539
1521-3765
DOI:10.1002/(SICI)1521-3765(19991001)5:10<2977::AID-CHEM2977>3.0.CO;2-T