Gd(DTPA-bisamide)alkyl Copolymers: A Hint for the Formation of MRI Contrast Agents with Very High Relaxivity

The separation of global and local motion for [Gd(DTPA−BA)−(CH2)n]x copolymers (see diagram) shows that, contrary to usual linear polymers, the global rotation can strongly contribute to proton relaxivity. The rate and mechanism of water exchange is not influenced by polymerization. The collective r...

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Bibliographic Details
Published in:Chemistry : a European journal 1999-04, Vol.5 (4), p.1202-1211
Main Authors: Tóth, Éva, Helm, Lothar, Kellar, Kenneth E., Merbach, André E.
Format: Article
Language:English
Subjects:
Contrast agents
Gadolinium complexes
Lanthanides
Life Sciences
Ligand exchange
Magnetic resonance imaging
NMR spectroscopy
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Summary:The separation of global and local motion for [Gd(DTPA−BA)−(CH2)n]x copolymers (see diagram) shows that, contrary to usual linear polymers, the global rotation can strongly contribute to proton relaxivity. The rate and mechanism of water exchange is not influenced by polymerization. The collective results for these three polymers have important implications for the design of polymeric species with very high proton relaxivities.
ISSN:0947-6539
1521-3765
DOI:10.1002/(SICI)1521-3765(19990401)5:4<1202::AID-CHEM1202>3.0.CO;2-Y