Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, w...

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Bibliographic Details
Published in:Biomaterials science 2017-01, Vol.5 (2), p.211-215
Main Authors: Olejniczak, Jason, Collet, Guillaume, Nguyen Huu, Viet Anh, Chan, Minnie, Lee, Sangeun, Almutairi, Adah
Format: Article
Language:English
Subjects:
Arrays
Azides - chemistry
Biodegradability
Biomedical materials
Chemical Sciences
Click Chemistry
Formulations
Lactic Acid - chemistry
Medical services
Nanoparticles
Nanoparticles - chemistry
Particle Size
Payloads
Polyglycolic Acid - chemistry
Polymers
Surface Properties
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Summary:Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, we employ a novel biodegradable azide containing polymer in the formulation of polymeric nanoparticles and show that these particles can then be functionalized, with biorthogonal click reactions, to alter their surface appearance and their ability to interact with biological systems.
ISSN:2047-4830
2047-4849
DOI:10.1039/c6bm00721j