A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based o...

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Bibliographic Details
Published in:Journal of theoretical biology 2016-04, Vol.394, p.68-76
Main Authors: Malaspinas, O., Turjman, A., Ribeiro de Sousa, D., Garcia-Cardena, G., Raes, M., Nguyen, P.-T. T., Zhang, Y., Courbebaisse, G., Lelubre, C., Zouaoui Boudjeltia, K., Chopard, B.
Format: Article
Language:English
Subjects:
Blood-flow
Cerebral aneurysm
Clotting
Computer Science
Computer Simulation
Hemorheology
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Intracranial Aneurysm - complications
Intracranial Aneurysm - pathology
Intracranial Aneurysm - physiopathology
Lattice Boltzmann
Life Sciences
Modeling and Simulation
Models, Biological
Numerical modelling
Physics
Quantitative Methods
RNA, Messenger - genetics
RNA, Messenger - metabolism
Spatio-Temporal Analysis
Stress, Mechanical
Thrombosis
Thrombosis - complications
Thrombosis - pathology
Thrombosis - physiopathology
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Summary:We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms. •New model numerical for thrombosis formation in cerebral aneurysms.•Stop of the thrombosis process is an emergent process.•Low shear-stress threshold for thrombosis initiation validated through an in vitro experiment.•Application on two spontaneous thrombosis cases.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2015.12.022