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Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid
A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the con...
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| Published in: | Bioorganic & medicinal chemistry letters 1998-06, Vol.8 (11), p.1419-1424 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c367t-2fd7afa1d6f61b1c37a21710dd036c66f63bf4ef4eb6ce573d4555b430785da23 |
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| cites | cdi_FETCH-LOGICAL-c367t-2fd7afa1d6f61b1c37a21710dd036c66f63bf4ef4eb6ce573d4555b430785da23 |
| container_end_page | 1424 |
| container_issue | 11 |
| container_start_page | 1419 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | BELLIER, B DA NASCIMENTO, S MEUDAL, H GINCEL, E ROQUES, B. P GARBAY, C |
| description | A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists. |
| doi_str_mv | 10.1016/S0960-894X(98)00231-5 |
| format | article |
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Drug treatments ; Pipecolic Acids - chemical synthesis ; Pipecolic Acids - chemistry ; Pipecolic Acids - pharmacology ; Protein Conformation ; Rats ; Receptor, Cholecystokinin B ; Receptors, Cholecystokinin - antagonists & inhibitors ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (11), p.1419-1424</ispartof><rights>1998 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-2fd7afa1d6f61b1c37a21710dd036c66f63bf4ef4eb6ce573d4555b430785da23</citedby><cites>FETCH-LOGICAL-c367t-2fd7afa1d6f61b1c37a21710dd036c66f63bf4ef4eb6ce573d4555b430785da23</cites><orcidid>0000-0002-9198-9162 ; 0000-0002-9642-3643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2264118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9871777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02122133$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>BELLIER, B</creatorcontrib><creatorcontrib>DA NASCIMENTO, S</creatorcontrib><creatorcontrib>MEUDAL, H</creatorcontrib><creatorcontrib>GINCEL, E</creatorcontrib><creatorcontrib>ROQUES, B. P</creatorcontrib><creatorcontrib>GARBAY, C</creatorcontrib><title>Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. 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Drug treatments</subject><subject>Pipecolic Acids - chemical synthesis</subject><subject>Pipecolic Acids - chemistry</subject><subject>Pipecolic Acids - pharmacology</subject><subject>Protein Conformation</subject><subject>Rats</subject><subject>Receptor, Cholecystokinin B</subject><subject>Receptors, Cholecystokinin - antagonists & inhibitors</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNo9kNtKxDAQhoMo63p4hIVeiOhFNZNje6mLJ1z0QgXvQpqkGuk2Neku-PZ2DywMDMx88w98CE0AXwEGcf2GS4HzomSfF2VxiTGhkPM9NAYmWE4Z5vtovEMO0VFKPxgDw4yN0KgsJEgpx-jpJSxdk5nQpj5q3zqbTafP-W1mfee6Pnib6bbXX6H1qU-ZddEvB6aOYZ51A2JC402mjbcn6KDWTXKn236MPu7v3qeP-ez14Wl6M8sNFbLPSW2lrjVYUQuowFCpCUjA1mIqjBimtKqZG6oSxnFJLeOcV4xiWXCrCT1Gl5vcb92oLvq5jn8qaK8eb2ZqNcMECAFKlzCw5xu2i-F34VKv5j4Z1zS6dWGRlCgBZAGrUL4BTQwpRVfvkgGrlW611q1WLlVZqLVuxYe7yfbBopo7u7va-h32Z9u9TkY3ddSt8WmHESIYQEH_AfhDhww</recordid><startdate>19980602</startdate><enddate>19980602</enddate><creator>BELLIER, B</creator><creator>DA NASCIMENTO, S</creator><creator>MEUDAL, H</creator><creator>GINCEL, E</creator><creator>ROQUES, B. 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Drug treatments</topic><topic>Pipecolic Acids - chemical synthesis</topic><topic>Pipecolic Acids - chemistry</topic><topic>Pipecolic Acids - pharmacology</topic><topic>Protein Conformation</topic><topic>Rats</topic><topic>Receptor, Cholecystokinin B</topic><topic>Receptors, Cholecystokinin - antagonists & inhibitors</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BELLIER, B</creatorcontrib><creatorcontrib>DA NASCIMENTO, S</creatorcontrib><creatorcontrib>MEUDAL, H</creatorcontrib><creatorcontrib>GINCEL, E</creatorcontrib><creatorcontrib>ROQUES, B. 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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (11), p.1419-1424 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02122133v1 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Biological and medical sciences Cerebral Cortex - metabolism CHO Cells Cholecystokinin - metabolism Cricetinae Guinea Pigs In Vitro Techniques Life Sciences Medical sciences Models, Molecular Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pancreas - metabolism Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Pipecolic Acids - chemical synthesis Pipecolic Acids - chemistry Pipecolic Acids - pharmacology Protein Conformation Rats Receptor, Cholecystokinin B Receptors, Cholecystokinin - antagonists & inhibitors Structure-Activity Relationship |
| title | Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid |
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