Muscle Loss Associated Changes of Oxylipin Signatures During Biological Aging: An Exploratory Study From the PROOF Cohort

Abstract Characterizations of the multiple mechanisms determining biological aging are required to better understand the etiology and identify early biomarkers of sarcopenia. Oxylipins refer to a large family of signaling lipids involved in the regulation of various biological processes that become...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2019-04, Vol.74 (5), p.608-615
Main Authors: Dalle, Céline, Ostermann, Annika Irmgard, Konrad, Thade, Coudy-Gandilhon, Cécile, Decourt, Alice, Barthélémy, Jean-Claude, Roche, Frédéric, Féasson, Léonard, Mazur, André, Béchet, Daniel, Schebb, Nils Helge, Gladine, Cécile
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Aged, 80 and over
Aging
Analytical chemistry
Angiogenesis
Biomarkers
Biomarkers - blood
Chemical Sciences
Etiology
Female
Food and Nutrition
Humans
Inflammation
Life Sciences
Lipids
Longitudinal Studies
Male
Metabolomics
Oxidative stress
Oxylipins - blood
Prospective Studies
Sarcopenia
Sarcopenia - blood
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Summary:Abstract Characterizations of the multiple mechanisms determining biological aging are required to better understand the etiology and identify early biomarkers of sarcopenia. Oxylipins refer to a large family of signaling lipids involved in the regulation of various biological processes that become dysregulated during aging. To investigate whether comprehensive oxylipin profiling could provide an integrated and fine characterization of the early phases of sarcopenia, we performed a quantitative targeted metabolomics of oxylipins in plasma of 81-year-old subjects from the PROOF cohort with decreased (n = 12), stable (n = 16), or increased appendicular muscle mass (n = 14). Multivariate and univariate analyses identified significant and concordant changes of oxylipin profiles according to the muscle status. Of note, 90% of the most discriminant oxylipins were derived from EPA and DHA and were increased in the sarcopenic subjects. The oxylipins signatures of sarcopenic subjects revealed subtle activation of inflammatory resolution pathways, coagulation processes, and oxidative stress as well as the inhibition of angiogenesis. Heat maps highlighted relationships between oxylipins and the cardiometabolic health parameters which were mainly lost in sarcopenic subjects. This exploratory study supports that targeted metabolomics of oxylipins could provide relevant and subtle characterization of early disturbances associated with muscle loss during aging.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/gly187