Distinct and dynamic myogenic populations in the vertebrate embryo

Myogenic cells in the body of vertebrates derive from the dorsal somite, the dermomyotome, where multipotent cells are present. Regulation of cell fate choice is discussed, as is that of progenitor cell self-renewal once cells have entered the myogenic programme. Ongoing research on the formation of...

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Bibliographic Details
Published in:Current opinion in genetics & development 2009-10, Vol.19 (5), p.444-453
Main Authors: Buckingham, Margaret, Vincent, Stéphane D
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - physiology
Development Biology
Embryo, Mammalian - cytology
Embryo, Nonmammalian - cytology
Embryology and Organogenesis
Extremities - embryology
Head - embryology
Humans
Life Sciences
Medical Education
Models, Biological
Multipotent Stem Cells - physiology
Muscle Development - physiology
Muscle, Skeletal - embryology
Vertebrates - embryology
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Summary:Myogenic cells in the body of vertebrates derive from the dorsal somite, the dermomyotome, where multipotent cells are present. Regulation of cell fate choice is discussed, as is that of progenitor cell self-renewal once cells have entered the myogenic programme. Ongoing research on the formation of the first skeletal muscle, the myotome, is presented with emphasis on mechanisms controlling the early segregation of slow and fast muscle lineages that characterizes this process in the zebrafish embryo. Further insights into myogenic populations that contribute to trunk and limb development at different stages are summarized and the distinct regulatory networks that underlie the formation of head muscles are discussed.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2009.08.001