Viral load and clinical manifestations of hepatitis E virus genotype 3 infections

A fraction of plasma donations undergoes hepatitis E virus (HEV) RNA screening since late 2014 in France. The aim of this study was to determine the frequency of HEV RNA as well as the viral load and the evolution of genotype distribution over a 3‐year period (2015‐2017) in asymptomatic blood donors...

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Bibliographic Details
Published in:Journal of viral hepatitis 2019-09, Vol.26 (9), p.1139-1142
Main Authors: Lhomme, Sebastien, Gallian, Pierre, Dimeglio, Chloé, Assal, Azzedine, Abravanel, Florence, Tiberghien, Pierre, Izopet, Jacques
Format: Article
Language:English
Subjects:
Adult
Antiretroviral drugs
Asymptomatic Infections / epidemiology
Blood & organ donations
Blood Donors
France / epidemiology
Genetic screening
Genotype
Genotype & phenotype
Genotypes
Hepatitis
Hepatitis E / blood
Hepatitis E / epidemiology
Hepatitis E / virology
hepatitis E virus
Hepatitis E virus / genetics
Hepatitis E virus / pathogenicity
Humans Immunoglobulin G / blood
Immunology
Life Sciences
Microbiology and Parasitology
Middle Aged
Ribonucleic acid
RNA
RNA viruses
RNA, Viral / blood
subgenotype distribution
symptomatic patients
Viral Load / statistics & numerical data
Virology
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Summary:A fraction of plasma donations undergoes hepatitis E virus (HEV) RNA screening since late 2014 in France. The aim of this study was to determine the frequency of HEV RNA as well as the viral load and the evolution of genotype distribution over a 3‐year period (2015‐2017) in asymptomatic blood donors in comparison with symptomatic patients routinely diagnosed. The overall detection rate of HEV RNA in plasma donations was 0.10% during the 3‐year period, with a median viral load of 717 IU/mL (range:
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.13128