Electric field induced DNA damage: an open door for selective mutations

Intense electric fields activate the mutagenic mechanism of a single guanine-cytosine base pair. Would they be able to induce a permanent mutation in real DNA? This question is addressed here by modeling a DNA-embedded fragment with state-of-the-art theoretical tools. We show how DNA can, in princip...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (69), p.7578-7580
Main Authors: Cerón-Carrasco, José Pedro, Jacquemin, Denis
Format: Article
Language:English
Subjects:
Base Pairing
Chemical Sciences
Cytosine - chemistry
DNA - chemistry
DNA - metabolism
DNA Damage
Electricity
Guanine - chemistry
Mutation
Thermodynamics
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Summary:Intense electric fields activate the mutagenic mechanism of a single guanine-cytosine base pair. Would they be able to induce a permanent mutation in real DNA? This question is addressed here by modeling a DNA-embedded fragment with state-of-the-art theoretical tools. We show how DNA can, in principle, be mutated if an appropriate electric field is applied.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc42593b