Maternal parity affects placental development, growth and metabolism of foals until 1 year and a half

• Published in: Theriogenology 2018-03, Vol.108, p.321-330
• Main Authors: Robles, M., Dubois, C., Gautier, C., Dahirel, M., Guenon, I., Bouraima-Lelong, H., Viguié, C., Wimel, L., Couturier-Tarrade, A., Chavatte-Palmer, P.
• Format: Article
• Language: English
• Subjects: Biochemistry, Molecular Biology; Cell Behavior; Cellular Biology; DOHaD; Horse; Life Sciences; Metabolism; Molecular biology; Parity; Placenta; Reproductive Biology; Sexual reproduction
• ISSN: 0093-691X; 1879-3231
• DOI: 10.1016/j.theriogenology.2017.12.019

Primiparous mares are known to produce smaller foals than multiparous mares. This difference seems to be partly explained by the reduced exchange surface and volume of the placental villi in primiparous compared to multiparous placentas. The effect of maternal parity on foals' post-natal growth, metabolism and sexual maturation, however, has been given little consideration. The objectives of this work were to analyse placental biometry and structure at term, growth of foals and yearlings, their metabolism and testicular maturation at one year of age. Twenty multiparous mares (M), aged over 6 years and 12 primiparous mares (P), aged up to 5 years were artificially inseminated with the same stallion and monitored the same way until foaling. At birth, foals and placentas were measured and placentas were sampled above at the umbilical cord insertion, as well as in the pregnant and the non-pregnant horn to perform stereological analyses. Foals were weighed and measured until 540 days of age. At 120 and 360 days of age, an Intravenous Glucose Tolerance Test was performed on foals and yearlings. At 360 days of age, the males were castrated and testicular maturation analysed by RT-qPCR. At birth, P dams produced lighter and smaller foals and placentas. The foal birth weight to placental surface ratio was lower in the P compared to the M group. P Foals remained lighter than M foals until 360 days of age and smaller until at least 540 days of age. At 120 days of age, P foals had a higher glucose tolerance than M foals, and then may be less mature than M foals in terms of the control of their glucose homeostasis. At 360 days of age, the testicles of prepubertal P stallions were less mature in the P vs the M group. In conclusion, primiparous dams produce intrauterine growth restricted, less mature and smaller foals compared to multiparous dams with altered metabolism and growth until at least 540 days of age. These differences could affect the sport career of these foals, especially if it begins at an early age. •Placentas of primiparous mares are lighter with a reduced capacity of histotrophic nutrition at term.•Foals born to primiparous mares are lighter until 12 months of age and smaller until 18 months of age.•Foals born to primiparous mares have less mature metabolic and male reproductive functions.