Coexpression of androgen receptor and FOXA1 in nonmetastatic triple-negative breast cancer: ancillary study from PACS08 trial

Microarray studies identified a subgroup of molecular apocrine tumors (estrogen receptor [ER] negative/androgen receptor [AR] positive) that express luminal genes including . FOXA1 may direct AR to sites normally occupied by ER in luminal tumors, inducing an estrogen-like gene program that stimulate...

Full description

Saved in:
Bibliographic Details
Published in:Future oncology (London, England) England), 2015-08, Vol.11 (16), p.2283-2297
Main Authors: Guiu, Séverine, Charon-Barra, Céline, Vernerey, Déwi, Fumoleau, Pierre, Campone, Mario, Spielmann, Marc, Roché, Henri, Mesleard, Christel, Arnould, Laurent, Lemonnier, Jérôme, Lacroix-Triki, Magali
Format: Article
Language:English
Subjects:
Adult
androgen receptor
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Cancer
Development and progression
Female
FOXA1
Gene Expression
Genetic aspects
Health aspects
Hepatocyte Nuclear Factor 3-alpha - genetics
Hepatocyte Nuclear Factor 3-alpha - metabolism
Humans
Immunohistochemistry
Life Sciences
Middle Aged
molecular apocrine tumors
Neoplasm Grading
Neoplasm Staging
Odds Ratio
Properties
Receptors, Androgen - genetics
Receptors, Androgen - metabolism
Transcription factors
Triple Negative Breast Neoplasms - drug therapy
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - pathology
triple-negative breast cancer
Tumor Burden
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microarray studies identified a subgroup of molecular apocrine tumors (estrogen receptor [ER] negative/androgen receptor [AR] positive) that express luminal genes including . FOXA1 may direct AR to sites normally occupied by ER in luminal tumors, inducing an estrogen-like gene program that stimulated proliferation. Expression of AR and FOXA1 was evaluated by immunohistochemistry in 592 patients with nonmetastatic triple-negative breast cancer (TNBC). Coexpression of AR and FOXA1 was found in 15.2% of patients. These tumors were more frequently lobular, found in older patients and exhibited a lower nuclear grade and a greater degree of node involvement. They less often exhibited lymphocytic infiltrate, pushing margins, syncytial architecture, central fibrosis or necrosis. TNBC with coexpression of AR and FOXA1 seems to behave like luminal tumors with a morphological profile distinct from other TNBC. These biomarkers could be useful to identify a subgroup of TNBC and could have future therapeutic implications.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon.15.102